role of the human papillomavirus infectio in esophageal squamous cell carcinoma
نویسندگان
چکیده
background and objective: human papillomavirus (hpv) is one of the possible etiologic factors in development of esophageal squamous cell carcinoma (escc). in this study we aimed to study the role of hpv in escc. patients and methods:in this study, 140 cases of escc were analyzed for the hpv dna by polymerase chain reaction (pcr) using gp5+/gp6+ primers for l1 open reading frame (orf) to amplify a 150-bp segment of hpv l1 orf. this region was subsequently sequenced to identify the type of hpv. results:a total of 140 patients enrolled in our study. in this respect, 50.7% of them were females and 49.3% were males, aged between 20 and 81 years old. in addition, 33 tumor specimens (23.6%) and 12 (8.6%) non-involved tumor margins were hpv positive. in hpv positive tumor cases, 36% were also positive in tumor margins. the hpv positive cases were 21.7% males and 25.3% females. there was no correlation between the presence and types of hpv with patients’ sex and age. the frequency of hpv subtypes in tumoral regions were as follow: hpv-16: 60.6%, hpv-18: 30.3%, hpv-33: 6.1%, and hpv-31: 3 %. we found only hpv-16 in tumor margins. conclusion:our results support a causal association between hpv infection and escc which is consistent with hpv studies conducted in other high-risk areas.
منابع مشابه
Role of the Human Papillomavirus Infectio in Esophageal Squamous Cell Carcinoma
Background and Objective: Human papillomavirus (HPV) is one of the possible etiologic factors in development of esophageal squamous cell carcinoma (ESCC). In this study we aimed to study the role of HPV in ESCC. Patients and Methods:In this study, 140 cases of ESCC were analyzed for the HPV DNA by polymerase chain reaction (PCR) using GP5+/GP6+ primers for L1 open reading frame (ORF) to am...
متن کاملRole of Brg1 in progression of esophageal squamous cell carcinoma
Objective(s): Epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as SWI/SNF. Brg1 also known as SMARCA4 is a catalytic subunit of SWI/SNF, which is necessary for MMPs expression. Matrix metalloproteinases (MMPs) are known as important player enzymes during tumor progression and metastasis. Aberrant epigenetic modification of chromatin should be...
متن کاملDetection of Human Papillomavirus DNA by PCR in Esophageal Squamous Cell Carcinoma from Turkmen Sahra, North-East of Iran
Human papillomavirus (HPV) DNA has been identified in esophageal carcinomas. However, the incidence of HPV varies significantly in different geographical locations. In this study, neoplasms from Turkmen Sahra, a region in Golestan province in northeast part of Iran, with a high incidence of squamous cell carcinoma were analyzed for the presence of HPV DNA. Turkmen Sahra is located in the cancer...
متن کاملDetection of Human Papillomavirus in Osophageal Squamous Cell Carcinoma samples in Mazandaran Province, Iran
We examined 170 formalin-fixed paraffin-embedded samples from esophageal squamous cell carcinoma patients. All subjects live in Mazandaran province, a region with high incidence rate of esophageal cancer and have become known as the “Asian Esophageal Cancer Belt”. Samples were tested for HPV-DNA by MY09/11 and Gp5+/6+ general primers using nested PCR. Of the 170 ESCC samples, 86 (50.6%) were ma...
متن کاملHigh-risk human papillomavirus in esophageal squamous cell carcinoma--letter.
BACKGROUND Although most cases of esophageal squamous cell carcinoma (ESCC) in western populations have been attributed to high levels of exposure to tobacco and alcohol, infectious agents have been postulated as possible causes, particularly human papillomavirus (HPV). METHODS To explore this issue, we analyzed HPV DNA prevalence and HPV types together with lifestyle factors, in relation to ...
متن کاملrole of brg1 in progression of esophageal squamous cell carcinoma
objective(s): epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as swi/snf. brg1 also known as smarca4 is a catalytic subunit of swi/snf, which is necessary for mmps expression. matrix metalloproteinases (mmps) are known as important player enzymes during tumor progression and metastasis. aberrant epigenetic modification of chromatin should be...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of pathologyناشر: iranian society of pathology
ISSN 1735-5303
دوره 2
شماره 1 2007
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023